ACAD108038

A postdoc position is available to join the group of Dr Adam Grieve to investigate the molecular mechanisms of plasma membrane proteostasis. This is an exciting interdisciplinary project, primarily using mammalian cell lines and primary neurons to discover and dissect the molecular mechanisms that shape the neuronal cell surface proteome to maintain human health and prevent disease.

You will be a member of an enthusiastic team within a thriving cell biology research community investigating aspects of dynamics of proteins at membranes and intercellular signalling. The role will involve the day-to-day independent running of the project, collaboration with other research groups within the School, performing a range of research tasks and assisting with training and supervision of postgraduate members of the lab.

What will you be doing?

A major goal of the project is the discovery and investigation of new regulators of membrane protein proteostasis. The project will employ techniques such as protein biochemistry, molecular cell biology, quantitative proteomics, flow cytometry and various forms of light microscopy.

You should apply if

You are enthusiastic about fundamental molecular and cellular mechanisms and discovery-based approaches. You are interested in performing cell biological and/or proteomic screens.

A PhD in a relevant biological or biomedical science is essential (awarded or imminent). You should also have prior knowledge of molecular cell biology, particularly the investigation of membrane protein traffic, turnover and/or signalling. Previous experience of gene editing, flow cytometry, high throughput screens or neuronal cell culture are highly desirable. You will be highly organised, eager to develop new skills and committed to interacting respectfully with a broad range of colleagues.