Laboratory Research Scientist - MANIFEST Research Platform / Human Biology Facility

An exciting Laboratory Research Scientist post is available for MANIFEST ("Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity"), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multi-omic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care. The Human Biology Facility includes the Human Sample Management Team and the Human Models Lab. This role will be embedded within the Human Biology Facility and as such will contribute to the day-to-day running of the relevant labs and work closely with this team, in addition to the MANIFEST platform team. The Human Sample Management Team (HSMT) is responsible for receiving human-derived samples, processing and logging the samples and carrying out assays. In addition the HSMT can processed blood samples for PBMCs. Depending on the study requirements, samples may be stored or prepared for serology assays, some of which are carried out by the team. Any sera, whole bloods or plasma that are leftover, are archived and tracked by the team. Key Responsibilities

• Receive, track, process, aliquot and assay samples
• Process a wide range of pathology specimens, including human tissue and blood
• Carry out tissue fragmentation preparation with fresh tissue collected as part of clinical trials to generate patient derived tissue fragments (PDTFs)
• Carry out DNA and RNA extraction from blood and tissue samples
• Effectively manage laboratory stock and equipment
• Become proficient in various Laboratory Information Management software systems required
• Understand and follow SOPs and Risk Assessments and be competent in all areas
• Become familiar and compliant with CL2 practices, HTA, GCP, Clinical Research Delivery and other regulatory requirements as needed