Biology Department, South Parks Road, Oxford, OX1 3RB, you may be relocated to the new Life and Mind Building when it is ready
The arms race at the plant-pathogen interface is a fascinating field of biology that can deliver important new, strategies for crop protection. Within this ERC-funded project, we used chemical proteomics to discover secreted plant proteins of Nicotiana benthamiana that are manipulated by Pseudomonas syringae during infection (e.g. Sueldo et al., New Phytol. 2024) and used artificial intelligence (e.g. Homma et al., Nat. Comm 2023) to predict pathogen proteins that might be responsible for this manipulation.
This project aims to elucidate the molecular mechanisms underpinning extracellular manipulation of the host during infection. You will use co-immunoprecipitation to verify predicted protein-protein interactions and establish enzymatic assays and activity-based labelling to demonstrate the effect of target manipulation. You will use reverse genetics to deplete the components from both plant and pathogen to demonstrate their importance in pathogen virulence and plant immunity.
We seek an enthusiastic colleague who has extensive experience in molecular cloning, protein expression and purification and who is keen to collaborate in an interdisciplinary research team.
Applications for this vacancy are to be made online via our e-recruitment system. Your supporting statement should explain how to meet each of the selection criteria for the post using examples of your skills and experience.
Where Covid-19 has resulted in substantial disruption to your work or research outputs, please explain this by providing an additional paragraph in your supporting statement.
The University of Oxford is committed to equality and valuing diversity. All applicants will be judged on merit, according to the selection criteria.