An exciting opportunity has arisen for a Research Assistant who is interested to work in the emerging area of organelle trafficking and dysfunction, in the context of neurodegenerative disease. This role will be based at the Target Discovery Institute, Nuffield Department of Medicine.

Reporting to the team leader, Dr Margarida Ruas, you will be responsible for maintaining mammalian cell cultures, including immortalized and ipsc-derived cell lines. You will carry out construction of expression vectors using a variety of molecular cloning techniques, plasmid DNA purifications, production of lentivirus for mammalian cell transduction, evaluation of protein localization using confocal microscopy, and other cell- and protein-based assays. You will carry out evaluation of the most appropriate methodologies to test hypotheses, adapt experimental protocols and contribute to wider project planning. You will also be responsible for general laboratory management, contribute to scientific reports and present the data/papers with other members of the groups.

It is essential that you hold a degree in Biochemistry, Cell/Molecular Biology or related together with a relevant laboratory experience. You will have knowledge of molecular biology techniques and immune-based techniques. You will be able to work flexibly, independently managing your own laboratory research, highly organized and have excellent interpersonal and communication skills. Having specific expertise relevant to organelle biology and/or neurobiology is highly desirable.

This position is offered full time on a fixed term contract until 30 April 2026 and is funded by the Alzheimer's Research UK.