ACAD107786

A post-doctoral position is available to develop new metalloprotein scaffolds and elaborate these into de novo enzymes. This post is available for 12 months in the first instance. It is in the protein design laboratory of Prof Dek Woolfson (Chemistry and Biochemistry, University of Bristol). The appointed post-doc would design de novo metalloenzymes based on new alpha-helical barrel proteins using computational design, and protein biochemistry.

The position would be suited to a talented and ambitious early career researcher with an interest in applying de novo protein design in biocatalysis and chemical or synthetic biology. Essential skills for the role include experience with the design or engineering and production of natural or de novo proteins; and the biophysical and structural characterisation of proteins, including crystallography. Experience in enzymology would be an advantage.