Associate Scientist - Protein Engineer

Within LMD, the Molecular Design and Engineering (MDE) group takes accountability for the engineering and development of single and multi-specific antibodies with enhanced functionalities as well as developability profiling prior to candidate selection, to transform leads into enhanced potential therapeutics. The Advanced Antibody Formats (AAF) team sits within MDE and is involved in a wide variety of activities during the design and prosecution of non-standard mAb (multi-specifics, mAb-protein fusions etc) programmes; the team works with stakeholders to identify and evaluate novel antibody formats, performing relevant antibody engineering, molecule production and characterisation studies, develops processes so the department can accommodate advanced format molecules, and works with and advises teams on bespoke project plans.,

• Produce multi-specific antibody-encoding expression constructs, including data registration in GSK databases.
• Work with our in-house antibody expression teams to coordinate/perform protein expression in mammalian cell culture systems and subsequent semi-automated purification.
• Perform biophysical characterisation of multi-specific antibody samples.
• Data analysis and interpretation. Deliver regular oral presentations to share data with project teams.
• Contribute to experimental design, planning and execution of technology development work packages., We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
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An opportunity is now available for a lab-focused enthusiastic Associate Scientist to join AAF to support the progression of multi-specific antibody therapeutic projects and to perform technology and process development work packages. We are looking for a highly motivated and self-starting scientist who is keen to continue developing their skills in both molecular biology and protein production (from expression through to purification and protein characterisation). The successful applicant will be comfortable working as part of a team and particularly enjoy working collaboratively.,
• Bachelor's degree, master's degree or equivalent experience in a life or chemical sciences subject (e.g. Biochemistry, Molecular Biology, Immunology or similar).
• Strong understanding of the fundamentals of molecular biology and protein engineering, with application to antibodies or antibody-related molecular formats.
• Demonstrated ability to work collaboratively as part of a team.
• Self-motivated, flexible approach with good organisational skills.
• Ability to review, assimilate and communicate new information effectively.
• Experience analysing and presenting scientific data packages.
Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
• Experience with protein expression and purification (in particular antibodies).
• Experience using software for DNA construct design and sequence analyses/validation.
• Experience with the analytical/biophysical characterisation of proteins.
• Knowledge of technologies that underpin bispecific antibodies, novel antibody formats, bioconjugation and/or altered antibody effector function.
• Understanding of industrial antibody discovery processes.
  
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