Clinical Research Fellow

To lead and undertake research of the highest quality in the broad area of perinatal neuroscience;

• Leading the development trial protocols providing intellectual input and supervising all aspects of day-to-day management of the COMET trial including regulatory approvals and amendments, and development of manual of operations Case recruitment and MR imaging from Imperial NHS Trust and liaising with the recruiting centres alongside the neonatal neurology research nurses Organising trial steering committee meetings and liaising with the data safety monitoring committee Attend and present work at international conferences
  
  The Centre for Perinatal Neuroscience within the Department of Brain Sciences is led by Professor Sudhin Thayyil and hosts one of the largest clinical research programs on neonatal encephalopathy in the world. Our work is focussed on prevention and treatment of neonatal encephalopathy and have direct health policy relevance. We have conducted some of the largest studies in the world on neonatal encephalopathy including Magnetic Resonance Imaging in Neonatal Encephalopathy (MARBLE study) (Lancet Neurology 2019) (BAPM guidelines 2020); Hypothermia for Encephalopathy in low and middle-income countries (HELIX) trial, Lancet Global Health 2021, JAMA Network 2023. Our group was first in the world to explain the biological mechanisms of neonatal encephalopathy using gene expression studies, and to highlight the hazards of therapeutic drift in use of induced hypothermia. We recently completed the world's largest study on birth related brain injury recruiting 80,000 mothers and babies from India
(NIHR RIGHT program) and is currently conducting the world's largest clinical trial of early and extended erythropoietin neuroprotection in neonatal encephalopathy (EMBRACE) in South Asia. We work closely with the engineering group at Imperial College London (Prof Aldo Faisal) on developing multimodal artificial intelligence predictive models using clinical, EEG and MR imaging data from these studies.