Laboratory Research Scientist - Briscoe Lab

The lab is looking for a highly motivated, proactive and enthusiastic researcher to help build upon the single-cell transcriptomics technology implemented in Maizels et al. The aim will be to develop affordable new sequencing technologies with increased throughput and resolution, facilitating novel research that would previously not be feasible. Firstly, this work will feed into multiple on-going projects within the lab studying the transcriptional dynamics that govern cell fate decisions. Additionally, this work will connect with the projects of multiple collaborators working across clinical, diagnostic and commercial settings, who wish to apply the technology to questions spanning cancer therapeutics, immune profiling, brain disorders and neurodegenerative diseases. The project will involve designing and performing experiments with tissue culture cells and carefully optimising novel genomics protocols. The Laboratory Research Scientist will work in collaboration with other lab members and the ability to work in a team is essential., These include but not limited to:

• Working with tissue culture cells
• Designing and performing sequencing and molecular biology experiments
• Operating automation protocols with liquid handling robots
• Record keeping
• Data analysis & interpretation
Key experience and competencies The candidate should be open-minded, creative, energetic and bring strong expertise and experimental background in at least one of the fields of molecular genetics, embryonic stem cell differentiation systems, or genomics technologies. Basic knowledge of molecular cell biology (e.g. cell culture, RT-qPCR, electrophoresis gels) is essential. Preference will be given to candidates with knowledge and experience in single-cell molecular biology methods and/or lab automation through liquid handling robotics.