Postdoctoral Fellow - Cancer Evolution and Genome Instability Laboratory

The Cancer Evolution and Genome Instability lab are studying how cancers evolve in the body to spread and become resistant to therapy and finding new ways to treat them more effectively. Lung cancer remains one of the most pressing public health concerns worldwide, demanding innovative research to address its complexities and challenges. To this end, our research presents two distinct yet intertwined project directions for a postdoc candidate. We are seeking applications from candidates with a broad range of competencies. The first research direction investigates the role of non-mutagenic carcinogens in lung cancer initiation. Recent studies have brought to light the fact that most carcinogens do not solely rely on DNA mutations to drive cancer development. The second research direction focuses on the impact of clonal hematopoiesis of indeterminate potential (CHIP)-the age-related acquisition of somatic mutations in hematopoietic stem cells-on lung cancer progression. Key Responsibilities The postholder will be responsible for:

• Working within the multi-disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond, including academic and industry partners
• Driving the project forward using relevant experimental and/or computational approaches
• Keeping up to date with the relevant literature in the field of cancer biology
• Attending and reporting research results at regular group meetings
• Contributing to the dissemination of scientific results by means of writing papers for publication and presenting orally and in poster form at national and international meetings
  
  Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.