Postdoctoral Research Associate in chemical biology and bioengineering

postdoctoral appointment in chemistry interfacing bioengineering, biomedical, and life sciences
Location: Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Rodney Porter Building, Sibthorp Rd, off South Parks Road, Oxford, OX1 3QU, The available projects for several postdoctoral appointments will build on previously-published foundational studies, and encompass wide-ranging areas in the broader context of organic chemistry and chemical biology including small-molecule probe engineering: including, (1) projects aimed at understanding and reprogramming subcellular metabolite trafficking and signaling mechanisms through the design and application of novel small-molecule probes; (2) projects targeting chemistry-driven innovations of advanced spatial & functional omics methods in multiple living models for fundamental and disease-specific investigations; (3) development of selective small-molecule inhibitors targeting proteins/pathways essential in anticancer and immunotherapeutic development. There is possibility to learn cell-based assays and cutting-edge biochemical assays, in line with candidates' interest to diversify and successful and timely production of desired molecules (and subsequent SAR)

Your profile: prospective candidates should have, by the time they begin work, a Ph.D. in chemistry or biological or medicinal chemistry, or broader life sciences. We welcome all interested aspiring interdisciplinary researchers with diverse backgrounds. Experience in organic chemistry, bioengineering, or biotechnology is a plus, but not strictly required.

The Aye laboratory based at Oxford Department of Chemistry is a multidisciplinary laboratory focusing on reactive small-molecule metabolite signaling as it pertains to intra- and intercellular communication and drug discovery. We have pioneered numerous novel and multi-award-winning chemical biology concepts and techniques that have been applied to important biological questions.

We offer: a laboratory that has won numerous awards lying at a nexus between numerous fields interfacing with chemistry. The successful candidate will enjoy unique state-of-the-art instrumentation, a team-playing environment where they can learn and develop, and projects that are aiming to make real-world impact. The facilities and infrastructure at Oxford are also fantastic. More information about our research group, including other active research themes, can be found at https://www.chem.ox.ac.uk/people/yimon-aye, Term of employment: full time initial one-year