Postdoctoral Researcher

The main purpose of the position is to develop computational models of meiotic crossover patterning, collaborating with the experimental group of Dr Chris Morgan also at the John Innes Centre. The models will enhance our understanding of how crossovers are positioned, using phase-separating coarsening dynamics. The position would suit an individual with a high degree of independence and vision, able to advance the project independently. The successful candidate will have a rare opportunity to work on fundamental biological processes in a truly interdisciplinary environment, with seamless collaboration with a leading experimental group.

The ideal candidate will possess (or soon complete) a PhD in Theoretical Physics, Bio-Mathematics or Computational Biology. They will possess a strong interest in biological problems and have achieved demonstrable scientific success in previous roles. Prior experience of biological modelling is desirable but not essential.

Applications are invited for a Postdoctoral Researcher to join the group of Prof Martin Howard in the Department of Computational and Systems Biology at the John Innes Centre, Norwich, UK.

About the John Innes Centre:

The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits. Our strategic vision, Healthy Plants, Healthy People, Healthy Planet, sets out our ambitious long-term goals for the game changing impact of our science globally.

Our employees enjoy access to state-of-the-art technology and a diverse range of specialist training opportunities, including support for leadership and management. Click here to find out more about working at the John Innes Centre.

About the Howard Group:

The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions.

Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. At present there are two main research areas in the group: understanding patterning dynamics in sub-cellular biological systems and probing how epigenetic memory states are set up and then stably maintained. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis, understanding how crossovers are rarely closely positioned in space, an intriguing phenomenon called crossover interference. For epigenetics, we work on both histone modification memory systems, as well as on DNA methylation.

The group regularly publishes in the most prominent multidisciplinary journals, with recent papers in Nature, Science, Cell Systems, eLife, Molecular Cell and PNAS. Several previous members of the Howard group now hold independent faculty positions of their own, including in Warwick, Glasgow, Sydney, Amsterdam and Munich.