Principal Laboratory Research Scientist

This is an excellent opportunity for a highly motivated senior scientist to be heavily involved in the start-up of a major laboratory and to provide senior level support in broad scientific management for the research group., The role of a Principal Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes.

• Independently undertaking own research projects, designing, and executing experiments with strategic direction from the group leader.


• Providing experimental or technical support to other lab members.


• Developing novel methodologies.


• Assisting the Group Leader in writing grant applications and managing research group governance


• Whenever required, deputising for the Group Leader at internal Crick meetings


• Managing long-term collaborations with other researchers.


• Participating in academic activities including presentations at lab meetings, Interest Group seminars and external scientific meetings.
  
  We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ's regenerative capacity in order to design novel therapeutics to augment biological function.
  
  We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng. et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration.