Production Scientist

An exciting opportunity has arisen for a highly motivated Production Scientist to join the Newcastle Advanced Therapies Team within the Pharmacy Directorate. Our cell, gene and tissue laboratory offers a comprehensive and flexible service to adult and paediatric patients, providing treatments for a wide range of complex conditions, including haematological disorders, oncology treatment and diabetic care.
+ Interview Date Thursday, 17 October 2024
+ 37 Hours 30 Minutes/Week
+ You will be redirected to Trac to apply for the vacancy. Please expand the job details section and read all of the information before applying for the vacancy, Specialist procedures include:
CD34^+selection
Red cell depletion and mononuclear cell preparation
TCRαβ^+ and CD19^+ depletion
CD45RA^+depletion, + To carry out preparation and / or cryopreservation of cells and tissues from donations, having successfully completed the in-house competency based training programme that encompasses the concepts of Quality Assurance, Regulatory Compliance with HTA & JACIE, GMP and Quality Control.
+ To carry out the manufacture of advanced therapeutic investigational medicinal products, from cells or tissue, having successfully completed the in-house competency based training programme that encompasses the concepts of Quality Assurance, Regulatory compliance with MHRA, GMP and Quality Control.
+ To oversee technical staff in the preparation of specimens for analysis, including the reception, processing, preservation, labelling, storage, distribution and disposal of products.
+ To maintain accurate and legible written and electronic records in accordance with local data integrity policy.
+ To operate, maintain and monitor clean rooms in accordance with
HTA/MHRA/JACIE requirements.
+ To assist in the recovery and infusion of cellular products.
+ To respond, troubleshoot and problem solve in the event of laboratory equipment faults, procedural complications or alarm states. Offering immediate corrective actions and subsequently implementing any required change.
+ To report faults and deviations to a senior member of staff and take prompt and appropriate action in response to unexpected situations, understanding when to escalate when limit or scope of practice is reached.
+ To carry out laboratory diagnostic tests, validate results and use knowledge and judgement to determining and initiate further tests or actions that may be required.
+ To provide advice, support and supervision to Technical staff and guest users of the facility.
+ To liaise closely with clinical teams and QC testing laboratories to coordinate receipt of cells, product testing and re-infusions across multiple sites.
+ To verify and relay critical information regarding donations and cellular products to the Newcastle Advanced Therapies team and service users which may have immediate impact on the management of the patient.
+ To attend clinical areas (wards, theatres) on any of the trust sites to assist clinical staff in the delivery and administration of Cell, Gene and Tissue products.
+ To be aware of the requirements from regulatory bodies applicable to the role (HTA, JACIE, MHRA) and perform all duties in accordance with the local Quality Assurance System to ensure regulatory compliance.
+ To participate in clinical trial activities in accordance with GMP and GCP requirements.
+ To participate in service and product improvement through continual education and training, taking an active role in policy, product and service development.
+ To participate in the departmental audit, correct and record minor non-compliance (deviation) and immediately report any major deviations to a senior member of staff as per local policy.
+ Take responsibility for own learning and development, maintaining a personal training record, ensuring all mandatory Trust and departmental training is performed in a timely manner.
+ To work in compliance with local health and safety rules to ensure a safe working environment for you, colleagues and visitors. To adhere to department and Trust Health and Safety policies (including COSHH, Risk assessments and Standard Operating Procedures) and to report any deviations from protocol to a senior member of staff.
As a flexible working friendly organisation, we want to be sure that you can work in a way that is best for us and for our patients, and for you. Speak to us about how we might be able to accommodate a flexible working arrangement. If it works for the service, we will do our best to make it work for you.
Please note it is a requirement of The Newcastle upon Tyne Hospitals NHS Foundation Trust that all successful candidates who require a DBS for the post they have been offered pay for their DBS certificate. The method of payment is a salary deduction from your first month's pay.
Important note on completion of reference section of Application Form
All references from current and previous employers will be sought and must cover a minimum of 3 years employment. Therefore, when completing the reference section of your application form, please give the address, telephone number and work email address of each of your current/previous line managers that cover 3 years employment. Failure to complete this section may result in your application not being processed.
Please note it is a requirement of The Newcastle upon Tyne Hospitals NHS Foundation Trust that all successful candidates who require a DBS for the post they have been offered pay for their DBS certificate. The method of payment is a salary deduction from your first month's pay.
Candidates who are shortlisted for interview will be contacted by e-mail. You should check your SPAM folders as well as your inbox. If you have not been contacted within 4 weeks of the closing date you should assume your application has been unsuccessful.

Newcastle Hospitals NHS Foundation Trust is one of the busiest, largest and most successful teaching NHS foundation trusts in the country, with around 16,000 staff and an annual income of £1 billion.
We have a long history of providing high quality care, clinical excellence, and innovation in medical research regionally, nationally and internationally.
We're also proud to be the second largest provider of specialised services in the country. This means we support people with a range of rare and complex medical, surgical and neurological conditions, cancers and genetic orders.
Our staff oversee around 1.84 million patients 'contacts' each year, delivering high standards of healthcare.
We are committed to promoting equality and diversity and recognise the benefit in providing an inclusive environment. We value and respect the diversity of our employees and aim to recruit a workforce which reflects the communities we serve, and is equipped to deliver the best service to our patients. We welcome all applications irrespective of people's race, disability, gender, sexual orientation, religion or belief, age, gender identity, marriage and civil partnership, pregnancy and maternity and in particular those from under- represented groups.
Newcastle Hospitals are proud to be one of the exemplar organisations across the NHS on sustainability, with a long history of delivering Sustainable Healthcare in Newcastle (Shine) and the first healthcare organisation in the world to declare a climate emergency. Our strategy includes commitments to being Net Zero by 2030, for our direct carbon footprint, and Net Zero by 2040 for our footprint plus. Delivering these ambitions will not be possible without the help, support and action of every single member of our team., Newcastle Hospitals NHS Foundation Trust is one of the busiest, largest and most successful teaching NHS foundation trusts in the country, with around 16,000 staff and an annual income of £1 billion.
We have a long history of providing high quality care, clinical excellence, and innovation in medical research regionally, nationally and internationally.
We're also proud to be the second largest provider of specialised services in the country. This means we support people with a range of rare and complex medical, surgical and neurological conditions, cancers and genetic orders.
Our staff oversee around 2 million patients 'contacts' each year, delivering high standards of healthcare.
Please see attached information on what Staff Benefits we have to offer at our Trust.
We are committed to promoting equality and diversity and recognise the benefit in providing an inclusive environment. We value and respect the diversity of our employees and aim to recruit a workforce which reflects the communities we serve, and is equipped to deliver the best service to our patients. We welcome all applications irrespective of people's race, disability, gender, sexual orientation, religion or belief, age, gender identity, marriage and civil partnership, pregnancy and maternity and in particular those from under- represented groups.