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Purification Scientist

PerkinElmer, Inc., Bedwell, Stevenage

Purification Scientist

Salary Not Specified

PerkinElmer, Inc., Bedwell, Stevenage

  • Full time
  • Permanent
  • Onsite working

Posted 3 weeks ago, 13 Sep | Get your application in now before you miss out!

Closing date: Closing date not specified

job Ref: faa8adcac95e4ccfa56dc2a676a646a8

Full Job Description

  • Deliver a flow process, involving varied instrumentation platforms, to enable the isolation of compounds of interest from crude mixtures.

  • Utilise relevant analytical instrumentation for separations method development; primarily analytical UPLC-MS.

  • Operate mass-directed automated purification (MDAP) HPLC platforms to purify complex, crude sample mixtures.

  • Identify desired chromatographic fractions and consolidate for isolation using liquid handling robots.

  • Removal of chromatographic purification solvents by lyophilisation and generation of post-purification analysis samples for multiple techniques, such as UPLC-MS and NMR.

  • Use liquid handling technology and other appropriate instrumentation (including nitrogen dry-down units and lyophilisation units) to dispense purified compounds for ongoing screening.

  • Oversee the collection of appropriate analytical data to characterise and register final drug candidate molecules prior to organising submission for screening.

  • Document purification conditions and method development used to isolate compounds and provide this information to the originating chemist.

  • Maintain instrumentation as appropriate and escalate any identified instrumentation or hardware issues that cannot be resolved locally to next level support, as determined by GSK.

  • Support CAPS scientists with evaluations of new chromatographic systems and related processes as appropriate.

  • Operate and maintain laboratory equipment in accordance with appropriate internal maintenance SOPs and work instructions.

  • Collect service metrics where applicable.

  • Follow all safety protocols and operating requirements as defined by local management and GSK policy.

  • Liaise with colleagues to determine the appropriate consumable provisions required to support ongoing CAPS progression.

  • Perform routine lab maintenance & organisation.

  • Support process improvement projects related to service deliverables as capacity allows and as approved by the PE team manager., The overall physical exertion of this position may require:

  • Sit or stand 4-5 hours in laboratory areas.

  • Reach above/below the shoulder, bend at the knees and waist.

  • Office work activities, including computer-based activities

  • Work around moving laboratory equipment and machinery.

  • Use of personal protective equipment in laboratory.

  • Work with biohazards such as hazardous compounds and chemical in compliance with local safety rules and regulations.


    • Working Environment
  • Must be able to work in a laboratory, controlled environment requiring personal protective equipment.

  • Job pace may be fast and job completion demands may be high.

  • Employee will be required to manage hazardous wastes in compliance with local company procedures & UK hazardous waste regulations. Duties may include: identifying, handling, generating, accumulating, storing, labelling and appropriate disposal.

  • Ensure safety, security, and environmental care in all aspect of the daily activities, and any potential safety hazards are addressed and corrected immediately.

  • Understand ergonomic relationship between people, equipment and working environment.

    Bachelor's degree with 3+ years of experience or Master's degree with 2+ years of experience in chemistry, analytical chemistry or a similar scientific discipline.

  • Demonstrated working familiarity with different analytical and preparative techniques.

  • Strong desire to learn with multifunctional learning agility.

  • Self-motivated.

  • Outstanding verbal and written communication.

  • Basic preparative instrumentation knowledge including simple maintenance and repair.

  • Ability to multitask across purification and analysis.

  • Ability to manage the workflow within the group.

  • Experience with analytical method development and preparative chromatography in small molecule pharmaceuticals.

  • Ability to analyse chromatographic data and make decisions for follow up experiments

  • Awareness of Waters analytical and preparative chromatography systems.