Research Assistant in Gene Regulation

MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford, OX3 9DS
Applications are invited for a Research Assistant to work with Prof Jim Hughes and Dr Matthew Baxter at the MRC Weatherall Institute of Molecular Medicine.
This is an exciting opportunity to work on developing cutting edge genomics methods for understanding how changes in the sequence of the human genome cause disease. You will work on a collaborative Wellcome Discovery Award that aims to develop laboratory based approaches for decoding how the human genome encodes gene expression levels. This project brings together world-leading experts in genomics, computational science, and clinicians studying globally significant diseases including Coronary Artery Disease. The project is a collaboration between James Davies' and Jim Hughes' laboratories. You will undertake large scale data generation from primary human samples using state-of-the-art genomics methodologies and will be responsible for the development and running of a standardised high throughput genomics pipeline, to produce custom Next Generation Sequencing libraries. Additionally, the role will involve using standard molecular methods and activities such as routine cell culture to
progress the research of the groups.

A minimum 2:1 degree in biological sciences with a period of relevant practical working experience within a laboratory is essential. You will have previous experience and sufficient knowledge in basic molecular biology protocols such as DNA purification, PCR, cloning. An interest in genetics, genomics, and gene regulation along with a good understanding of Next Generation Sequencing techniques is required. Experience in genomics assays including open chromatin assays, ChIP-seq, RNA-seq and ideally Chromosome Conformation Capture is desirable.