Research Associate (Fixed Term)

The candidate will join a multidisciplinary group of basic and clinician scientists to pursue fundamental and clinically relevant questions in neurobiology. The laboratory is based in the John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, with affiliation to the MRC-WT Cambridge Stem Cell Institute, leading centres dedicated to Regenerative Neurobiology, Restorative Neurology and Data Science. The appointee will join a vibrant and international research environment in the Cambridge Biomedical Campus, which has a strong track record for empowering exceptional scientists and supporting the career development of postdoctoral researchers from diverse backgrounds.

Key References: Szebényi, K., Barrio-Hernandez, I., Gibbons, G.M., Biasetti, L., Troakes, C., Beltrao, P., and Lakatos, A. A human proteogenomic-cellular framework identifies KIF5A as a modulator of astrocyte process integrity with relevance to ALS (2023).

Communications Biology 6, 678 Szebényi, K., Wenger, L.M.D., Sun, Y., Dunn, A.W.E., Limegrover, C.A., Gibbons, G., Conci, E., Paulsen, O., Mierau, S.B., Balmus, G., and Lakatos, A. Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology (2021). Nature neuroscience 24, 1542-1554 Giandomenico, S.L., Mierau, S.B., Gibbons, G.M., Wenger, L.M.D., Masullo, L., Sit, T., Sutcliffe, M., Boulanger, J., Tripodi, M., Derivery, E., Paulsen, O., Lakatos, A., Lancaster, M. Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output (2019). Nature neuroscience 22(4):669-679

The candidate must have a PhD or MD in biological or medical sciences and practical experience with stem cell or cell-line cultures, general cell and molecular biology methods, vector preparation, and cloning. Further experience in one of the following specific areas is desirable: human stem cell- or organoid-based cultures, genetics and CRISPR-editing, single-cell transcriptomics, proteomics, or molecular pathology expertise.