Research Associate in Cell Biology x 2 (Fixed Term)

We are seeking multiple postdoctoral research associates to work on organoid models of rare respiratory pathologies including interstitial and cystic lung diseases. Funded by Action for Pulmonary Fibrosis and the LifeArc Centre for Rare Respiratory Diseases, the research associates will create organoid models allowing the study of fundamental disease mechanisms and enabling the development of novel therapies.

Our lab in the Cambridge Institute for Medical Research has a proven track record in elucidating the mechanisms underlying rare respiratory diseases with a focus on defects of protein folding and trafficking. We have extensive expertise in disease models, forward genetic screens, advanced microscopy, and multi-omics analysis. Successful applicants will join Professor Marciniak and Dr Dickens as part of a diverse team of scientists and clinicians committed to excellence in scientific research and in creating a rewarding and healthy working environment.

The LifeArc Centre for Rare Respiratory Diseases seeks to unite children, adults and families affected by relevant conditions with clinical experts, researchers, investors and industry leaders to accelerate diagnosis and development of much-needed therapies (https://www.cam.ac.uk/research/news/rare-disease-research-at-cambridge-receives-major-boost-with-launch-of-two-new-centres). The Centre is a partnership between Universities and NHS Trusts, co-led by partners in Cambridge, Edinburgh, Nottingham, Dundee, Southampton and London. It is supported by patient groups including Action for Pulmonary Fibrosis and the Birt-Hogg-Dubé Foundation. The postdoctoral associates will have the opportunity to interact productively with academics, clinicians, and patient advocates involved in the Centre across the UK.

Applicants should hold a PhD in wet-lab cell biology. Prior experience of organoid culture, complex genetic editing and/or mechanistic protein biology would be advantageous though additional training will be provided where necessary.