Research Associate (Mass Spectrometry-based Metabolomics)

An exciting Research Associate position has opened to discover metabolic mediators associated with the transition from health to imminent disease in relation to the nutrition-microbiome-metabolite-immune axis and the transition from health to disease as part of the IMMEDIATE consortium., We are looking for a Postdoctoral Research Associate in Mass Spectrometry - based Metabolomics to join the headed by Prof. Dumas and characterise the human metabolome in relation to the microbiome and inflammation as part of the . You will undertake a high-resolution mass spectrometry-based of the metabolome of the IMMEDIATE volunteers to investigate the diet-microbiome-metabolome-immune axis. You will coordinate metabolic profiling by high-resolution accurate mass spectrometry on human clinical studies in the IMMEDIATE consortium; and collaborate with other consortium partners on the development of the concept diet-microbiome-metabolome-immune axis and its role in the transition from health to disease. The project includes optimisation of chromatographic and mass spectrometric conditions, metabolite identification, development of a comprehensive standards database and metabolomic analysis in human biofluids. The project will focus particularly on global profiling of the human metabolome in various matrices. You will contribute to developing and implementing ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) to profile the metabolome, enhance metabolite identification and how these metabolites contribute to the transition from health to disease. The project will have a special focus on i) identification of microbiome-derived bioactive metabolites involved in the diet-microbiome-metabolite-immune axis, ii) assessing how this axis plays a role in the transition from heath to disease, iii) defining whether this axis is conserved with the transition to disease and whether the axis changes with age. You will play a role in influencing the project. Based on findings, the role may include development of new analytical, chemoinformatic or bioinformatic workflows, management, and population of pure chemical standards databases and / or biological mechanism hypothesis generation. In addition, you will also help coordinate metabolomics activities among projects within the Division of Systems Medicine, helping with data generation and integration with other omics datasets produced as part of the section and division activities

• Experience in interdisciplinary research and managing large integrated development projects.
  
  You must have a PhD in Analytical Chemistry, Biochemistry or related field with a strong expertise in mass spectrometry for metabolomics. You will need to have experience in interdisciplinary research and managing large integrated development projects.
  
  Access to world-class research facilities at Imperial College London.
• Hybrid working options to support work-life balance.
• The opportunity to continue your career at a world-leading institution
• Sector-leading salary and remuneration package (including 39 days off a year)