Research Associate - The Study of Adenosine A2A Receptor Pharmacology and Dimerization University of Nottingham Nottingham, United Kingdom

The role will provide support to an ongoing new MRC programme grant that aims to exploit a novel molecular toolkit to explore cell type specific adenosine receptor pharmacology and regulation at endogenous levels of expression. The successful candidate will join a team of postdocs supporting this programme and will be specifically involved in the study of adenosine A2A receptor pharmacology and dimerization. The work will involve novel fluorescence based assays and state-of-the-art imaging to unravel the interaction of A2A receptors with other cell surface receptors using 3D cell culture models involving multiple cell types, such as endothelial, fibroblasts and cancers cells (for cancer models).

The role holder will work closely with a postdoctoral medicinal chemist and undertake resonance energy transfer measurements (both BRET and TR-FRET), confocal and super-resolution imaging, fluorescence correlation spectroscopy (FCS), CRISPR/Cas9 genome editing and complex molecular and cellular biology.

Candidates should have a PhD (or close to completion) or equivalent in molecular pharmacology or a related subject area, along with previous experience with using bioluminescence resonance energy transfer techniques (BRET) and both fluorescence correlation spectroscopy and photon counting histogram approaches. The candidate should also have previous research experience of the molecular pharmacological characterisation of G protein coupled receptors (GPCRs).