Research Fellow (109970-1224)

There is funding to appoint a Research Fellow for up to 36 months. The duration may need to be shortened up to a maximum of 35 months depending on the starting salary of the successful candidate. Appointments are subject to approval from the Leverhulme Trust., We are looking to hire a postdoctoral researcher to work on a Leverhulme Trust funded project within the research group of Dr. Orkun Soyer. This project is a collaboration between Soyer's group at the University of Warwick and Prof. Wenying Shou at the University College London. The overall aim of the project is to understand the role of metabolic co-substrates (and in particular NADH) in the regulation of the respiration - fermentation flux switch. Our work combines mathematical modelling and experimentation in yeast and this post will focus on the experimental work at the single-cell level.

Candidates should have a background in quantitative biology, cell biology, biochemistry, biophysics, engineering, or microbial physiology. Candidates should have experience in one or multiple of the key quantitative techniques such as fluorescent microscopy, image analysis, microfluidics, metabolomics, and transcriptomics. They should have experience in working with yeast or more broadly in cell culture and in experiment design and conduct. Ideal candidates should be familiar with any one or multiple of these, or similar, techniques.

KEYWORDS: - [quantitative biology, cell metabolism, system dynamics, fluorescent microscopy, cell physiology]

What scientific question will you investigate? / Outline of the project aims

This project will focus on the respiration-fermentation switch seen across microbial and mammalian cells, including cancer cells. The regulatory basis of this switch remains elusive. With this project, we will specifically test predictions from our ongoing mathematical modelling work, where we focus on the role of co-substrate dynamics - particularly NADH dynamics - in regulating fluxes at metabolic branch points.