Senior Laboratory Research Scientist

The role of a Senior Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations.

• Developing new techniques and protocols that are critical to the laboratory.
• Assisting the group leader with daily tasks.
• Engaging in and advancing a variety of scientific projects.
• Fostering collaboration with different laboratories within the Crick.
• Instructing both current and new lab members in general protocols and techniques that are commonly used in the lab.
• Drafting, executing, and revising Safety Assessments.
• Creating, implementing, and revising mouse protocols.
• Managing the care of complex genetically modified mouse colonies.
• Overseeing lab management.
• Sharing experimental results and discoveries both within and beyond the Crick.
  
  The Research Group
The laboratory of Tumour-Immune Communication has been established in early 2024. We study bidirectional interactions between cancer cells and the host immune system using synthetic and molecular biology, genetics, and immunology. This research delineates how interaction dynamics between tumour cells and immune cells influence each other, contributing to our understanding of tumour progression and antitumour immune response. The Chudnovskiy laboratory's research in tumour immunology is directed at three pivotal questions. The first examines how tumour cells induce immune cell exhaustion, leading to a weakened response against the tumour. The second question investigates the evolution of tumour cells to evade the immune system's cytotoxic cells. The third investigates how tumours manipulate antigen presentation to shift T cell responses from being immune-reactive to tolerant of tumour antigens. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/aleksey-chudnovskiy Research techniques used in the laboratory include: We utilize immunological, genetic, genomic, molecular and synthetic biology techniques to study tumour immunology.