Senior Laboratory Research Scientist

We are looking for an enthusiastic and proactive scientist to work with us within our EPSRC-funded Prosperity Partnership collaboration between the Francis Crick Institute and GSK. In this collaboration we are employing covalent fragment screening to simultaneously identify potential new drug targets and small molecules tools. See: https://www.crick.ac.uk/news/2021-04-02_francis-crick-institute-and-gsk-to-pioneer-reactive-fragment-screening-in-drug-discovery We have already established a high-throughput chemoproteomic platform that enables covalent fragment screening in cells and have identified many novel protein-small molecule interactions which we now want to explore and develop into high quality molecular probes. We are now looking for a Senior Laboratory Research Scientist to join our multi-disciplinary team and work with us on the biochemical and structural characterisation of these newly identified protein-compound interactions to support the rapid generation of tool molecules for disease-relevant protein targets. The role will focus on work within the EPSRC- funded Crick-GSK Prosperity Partnership collaboration.,

• Production of recombinant proteins and subsequent biochemical and structural characterisation of protein-compound complexes
• Establishing biochemical and biophysical assays to study the effect of compound engagement on enzymatic activities or protein-protein interactions
• Working closely with chemists to explore structure-activity relationships
• Collaborating with other lab members on research projects.
• Participating and presenting in group meetings, seminars, and scientific meetings.
• Writing up findings for publication.
  
  The post holder should embody and demonstrate our core Crick values:
Bold; Open; Collegial Essential
• PhD or M.Sc. in biochemistry or related discipline,
• Broad experience in recombinant protein production
• Experience in the use of biophysical techniques to study protein-protein and protein-ligand interactions
• Excellent technical and problem-solving skills
• Excellent organisational and time-management skills
• Self-motivated with the ability to work both independently and as part of a team
• Strong communication skills to work with diverse scientists