Senior Postdoctoral Research Associate in Biochemistry & Drug Design

Join the University of Sheffield for an outstanding opportunity in groundbreaking drug development research. You can contribute to the fight against antibiotic-resistant bacteria by studying flap endonucleases (FENs) and their role in cell survival. We seek an experienced scientist (biochemist) to explore FEN-inhibitor interactions using a range of characterisation techniques., As a Postdoctoral Research Associate, you will:

• Conduct advanced research on FEN-inhibitor interactions using molecular interaction analysis, thermal shift assays, and FRET-based nuclease assays.
• Maintain accurate chemical structure databases, using DataWarrior for curation and PyMOL.
• Co-ordinate research activities with our international collaborators, showcasing your strong organisational skills.
• Contribute to preparation of research reports, publications, and presentations.
• Engage in collaborative research projects to identify new drugs for treating critical diseases.
• Participate in laboratory meetings, seminars, and conferences to present your findings.
• Ensure compliance with all safety and ethical guidelines in your research activities.
  
  To be successful in this role, you must have:
- A Ph.D. or equivalent experience in Biochemistry, Molecular Biology, Structural Biology, or a related field. - Proven experience in biophysics, including molecular interaction analysis, thermal shift assays, and FRET-based nuclease assays. - Proficiency in using DataWarrior for chemical structure curation and PyMOL for structural analysis and presentation. - Outstanding organizational skills and a proven ability to manage multiple projects and deadlines. - Strong communication skills, both written and verbal, to effectively present research findings and collaborate with team members. - A dedication to encouraging an inclusive and collaborative research environment. - The ability to work independently and as part of a team, demonstrating an ambitious approach to research., If you are passionate about scientific discovery and eager to contribute to world-class research, we encourage you to apply. Please submit your CV, a cover letter outlining your relevant experience and why you are interested in this position, and contact information for three professional references. Applications will be reviewed on a rolling basis, so early submission is highly encouraged., We are seeking candidates with a Ph.D. in a relevant area, as well as demonstrable experience in flap endonuclease inhibitor discovery research. As this role involves a multidisciplinary approach, it is essential that you have expertise in relevant chemoinformatics, biochemical and biophysical techniques and you will also need experience/knowledge of Python, PyRx and PyMOL.

You will join a team of researchers led by Prof. Jon Sayers which includes structural biologists dedicated to identifying potential new drugs to treat important diseases. The team has access to state-of-the art protein purification and analytical services, modern labs and the full range of equipment and facilities required to conduct cutting-edge research (see https://tinyurl.com/anzkmry3 for further information about FENs and the laboratory)., To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.


• 41 days annual leave (including closure days and Bank Holidays), with the possibility to purchase up to ten additional days.
• Up to 5 days of paid time off to cover emergency caring responsibilities.
• A highly competitive pension scheme.
• Discounts at participating shops and cinemas, and a cycle to work scheme.
• A commitment to your development, with programmes, learning modules and mentoring schemes.
• An inclusive and diverse workplace.
• A commitment to your wellbeing, with confidential emotional support, support for those going through the menopause, experiencing fertility treatment and having a baby, paid leave for IVF treatment and more., We're one of the best not-for-profit organisations to work for in the UK. The University's Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.