Senior Scientist, Process Development (Downstream).

We are currently recruiting for Senior Downstream Scientists to join the Process Development team. The purpose of this role is to plan, execute and report relevant downstream studies or investigations, and to support and supervise other members of the Group as needed to meet the Department objectives. Process Development (PD) is responsible for the development of world-class viral vector manufacturing processes for OXB's partnered programmes. PD performs a crucial technical role in OXB mission to deliver life-changing gene therapies to patients.,

• Involvement in activities ranging from vector production at laboratory and pilot scales, process development and optimisation, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
• Responsibility for designing and co-ordinating execution of downstream vector purification and formulation activities for scale-up/scale-down of existing bioprocesses.
• Analyse and interpret experimental data and report results to stakeholders (internally to OXB and externally to clients).
• Write, revise, review and approve SOPs, technical reports, and risk assessments, where appropriate.
• Ensure that the experiments are conducted within the team/project, and their interpretation and reporting are of the highest quality.
• Provide direction for a small team and/or projects in line with department and company objectives.
• Ensure that all work carried-out in the laboratory is performed efficiently and safely, following OXB HSE procedures.
• Carry out such other tasks as are required from time to time for the efficient running of the Company's business upon request from your line manager or a Director of the Company.
  
  BSc, MSc or PhD (or equivalent) in a relevant Bioscience
• Advanced understanding of downstream purification principles and relevant laboratory experience in one or more of the following areas: downstream process development, clarification, chromatography, tangential flow filtration, sterile filtration, product formulation.
• Demonstrated process scale up and tech transfer expertise
• Experience with the operation of laboratory, pilot or production scale downstream purification processes.
• Understanding of laboratory health and safety requirements.
• Competency in data capture, reporting and management systems.
• Familiar with data analysis software packages such as but not limited to Microsoft Excel, JMP, Design Expert , GraphPad Prism
• High level of familiarity with the current literature relating to research projects.
• Excellent written and verbal communication and presentation skills.
• Fluency in written and spoken English.
  
  Oxford Biomedica is a quality and innovation-led viral vector CDMO with a mission to enable its clients to deliver life changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, we have more than 25 years of experience in viral vectors; the driving force behind the majority of gene therapies.
Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods, and depth of regulatory expertise. What's in it for you:
• Highly competitive total reward packages.
• Wellbeing programmes.
• Development opportunities.
• Welcoming, friendly, supportive colleagues.
• A diverse and inclusive working environment.
• Our values are: Respect, Resiliance, Responsive & Responsible.
• State of the art laboratory and manufacturing facilities.
Collaborate. Contribute. Change lives.