Systems Modelling and Simulations Expert

As experts in the field, our team implements Process Systems Engineering, Modelling and Simulations approaches on medicines in development to increase understanding and greatly reduce labor, materials and time required to identify commercial manufacturing processes. The team provides support to the entire GSK portfolio across Small Molecule Drug Substances and Drug Products, Biopharmaceuticals and Vaccines. The Systems Modelling & Simulation Expert will also support upskilling of project team members to expand the use of models and simulations, as well as work with internal and external technical experts to develop and maintain core simulation software platforms. We also champion the integration of new ways of working into existing pharmaceutical "Quality by Design" workflows (eg; Process Design, Control Strategy Definition, Risk Assessment), regulatory filing strategies, and product life-cycle support.,

• Develop and deploy Process Systems Engineering, Modelling and Simulations approaches to the diverse GSK portfolio across small Molecule Drug Substance, Drug Product, Biopharmaceuticals and Vaccines.
• Pioneer and develop novel approaches including but not limited to mechanistic modelling, systems modelling, multiscale modelling (e.g. Computational Fluido Dynamics).
• Translate mathematical models to computer models using software platforms (e.g. gPROMS, DynoChem, Ansys, COMSOL) or by developing custom solutions (e.g. in Matlab, Python, etc.)
• Use engineering, chemical, biological or materials science knowledge to postulate mechanisms for physiochemical and biological processes and develop or modify existing mathematical models to describe those mechanisms.
• Package models into web applications to ensure accessibility and support the development of colleagues in engineering, chemistry and formulation science in using modelling tools.
• Develop and maintain key modelling platforms (e.g. gPROMS for systems modelling, Matlab for web applications).
• Direct experimentation and the analysis required to develop models and assess their credibility (e.g. parameter estimation).
• Stay current with new modelling techniques through external publications and conferences and academic and pre-competitive collaborations.
• Leverage external expertise and funding through alliances and academic collaborations to identify, develop and internalize novel modelling approaches for process development.
• As part of a matrix process development team, use Process Systems Engineering, Modelling and Simulations to efficiently deliver team priorities, including but not limited to Process Design, quantitative Risk Assessment, Identification of Critical Process Parameters / Design Space and implementation of advanced process controls.
• Provide and coordinate training and real-time support to expand the use of modelling (simulations) across the Development and Manufacturing environments.
• Work closely with the Subject Matter Experts in Pharmaceutical Quality by Design, regulatory and Information Technology to integrate process modelling into process development routine ways of working and drive cultural changes in the adoption of Digital, Data and Analytics across the organization.
• Advocate and comply with Good Manufacturing Practice (GMP) and Data Integrity requirements for recording experiments and associated data and authoring technical reports including scientific peer review and data checking.
• Provide input to budgets, recommend capital purchases of software supporting modelling.
• Comply with requirements on Safety, Quality for the Patient and GSK policies and procedures (sites and department)., We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or . Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive . As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

We are seeking an experienced and highly capable person who can demonstrate that they are passionate about simulation and modelling solutions.,
• PhD in process systems engineering, with an emphasis on development and implementation of process models and simulations.
• Experience of working as a technical expert in process modelling within the pharmaceutical industry.
• Demonstrated ability to translate mathematical models into computer programs (e.g., using Matlab, Python, gPROMS or similar software tools).
Preferred Qualifications:
• Experience with process engineering software (e.g., gPROMS, Dynochem, Ansys, COMSOL) and with programming languages (e.g., Python, Matlab).
• Experience in driving changes to scientific workflows through digital transformation in a large organization.
  
  Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

GSK offers a range of benefits to its employees, which include, but are not limited to:
• Competitive base Salary
• Annual bonus based on company performance
• Opportunities to partake in on-the-job training courses
• Opportunities for support for professional development and chartership (accreditations and professional bodies)
• Access to healthcare and wellbeing programmes
• Employee recognition programmes
If you would like to learn more about our company wide benefits and life at GSK we would suggest looking at our webpage Life at GSK | GSK.