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Principal Laboratory Research Scientist

The Francis Crick Institute, City of Westminster

Principal Laboratory Research Scientist

Salary not available. View on company website.

The Francis Crick Institute, City of Westminster

  • Full time
  • Permanent
  • Remote working

Posted today, 26 Nov | Get your application in now to be one of the first to apply.

Closing date: Closing date not specified

job Ref: 594daa6c5b80408c8671ddca5233fb90

Full Job Description

  • Independently devising and leading projects within the TRCE research program
  • Establishing new methodologies in the lab
  • Maintaining laboratory organisation and supplies
  • Supporting the Group Leader in day-to-day operations
  • Deputising for when the Group Leader is unavailable
  • Training and supporting lab members in standard operating procedures
  • Facilitating collaborations within and outside the Crick
  • Provision of technical and research support in the area of human stem cell biology including the tissue culture of pluripotent stem cells and organoids
  • Human cell engineering encompassing molecular biology and CRISPR/Cas gene editing
  • Management of regulatory protocols and research governance for the lab

    We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ's regenerative capacity in order to design novel therapeutics to augment biological function.

    We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng. et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration.

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